The Toxicological Effect and Risk Assessment (TERA) Knowledge Graph is an integrated knowledge graph for ecological risk assessment based on chemical effect data from U.S. EPA ECOTOX. TERA aligns toxicological data to non-proprietary identifiers using ontology alignment tools and external sources such as Wikidata, enabling the use of external chemical knowledge graphs including ChEBI, PubChem, and MeSH. The knowledge graph also includes aggregated data from NCBI Taxonomy and Encyclopedia of Life (EOL) trait data. By linking ECOTOX to external sources, TERA enables the extrapolation of chemical effect data, extending the reach of ecological risk assessment while limiting the need for laboratory experiments. The knowledge graph has been applied to predict adverse biological effects of chemicals using knowledge graph embeddings and supports various applications in environmental toxicology and risk assessment.
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